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The Business Magazine May 2024
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OrthoSon completes £8.9 million expanded Series A to accelerate back pain treatment’s progress to clinic

The Business Magazine article image for: OrthoSon completes £8.9 million expanded Series A to accelerate back pain treatment’s progress to clinic

Oxford-based medical equipment firm OrthoSon, which is developing novel motion-restoring minimally invasive treatments for low back pain, has announced thecompletion of an £8.9 million Series A fund round to help prepare its product for Phase I trials in the US.

New international investors in the expanded round include the Greek technology venture capital firm Big Pi Ventures and the Chinese investment company Yonghua Capital.

Plans for this investment include completion of preclinical safety studies, plus regulatory activity to prepare for US clinical trials expected to take place from 2024. This will be followed by European and international clinical trials supporting global launch.

With the completion of this Series A fundraising, OrthoSon’s Board will be strengthened as Aristos Doxiadis, Partner at Big Pi Ventures, and Wang Chong, Venture Partner at Yonghua Capital, join as Director and Observer respectively. Existing investors also participated in the financing.

OrthoSon’s proprietary back pain treatment is based on ultrasound and in-situ curing hydrogel implants to replace degenerated spinal discs.

Initially focusing on patients with lower back pain who are considering surgery, the company is targeting a market worth in excess of $1 billion.

It expects its innovative spinal disc restoration approach to be disruptively cost effective and safe compared with current surgical approaches, allowing patients to be treated in a minimally invasive way on a day-case basis with an anticipated reduction in both complications and use of opioid pain medication.

Rich Simmonds, CEO of OrthoSon, said: "This oversubscribed Series A round will take our novel motion-restoring spinal treatment through preclinical trials ahead of clinical trials in the US and internationally.

"OrthoSon would like to thank existing investors for their support and welcome new investors, including Big Pi Ventures and Yonghua Capital, to the company. We look forward to working with them as we develop our innovative technology to treat thousands of patients with crippling lower back pain."

Aristos Doxiadis, Partner at Big Pi Ventures, said: "We like to invest in companies which have strong technologies, teams and market positions, and OrthoSon has all of these. Big Pi Ventures believes its product will have a significant impact on the back pain market, improving quality of life for sufferers and reducing healthcare costs and disability."

Wang Chong, Venture Partner at Yonghua Capital, said: "As experienced investors in novel medical technology, we are excited by the potential of OrthoSon’s novel solution to the global problem of back pain.

"We are enthusiastic about the progress in focused ultrasound therapy and Yonghua is looking forward to working with the company to bring this product to the market."


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Peter Davison is deputy editor of The Business Magazine. He has spent his life in journalism – doing work experience in newsrooms in and around Bristol while still at school, and landing his first job on a local newspaper aged 19. By 28 he was the youngest newspaper editor in the country.

An early advocate of online news, he spent the first years of the 2000s telling his bosses that the internet posed both the biggest opportunity and greatest threat to the newspaper industry and the art of journalism. He was right on both counts.

Since 2006 he has enjoyed a career as a freelance journalist. He lives in rural Wiltshire with one wife, two children, and three cats.

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