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GeninCode collaborates with Indiana University School of Medicine

The Business Magazine article image for: GeninCode collaborates with Indiana University School of Medicine
24 March 2022

GENinCode Plc, the Oxford-based predictive genetics company focused on preventing cardiovascular disease is to collaborate with the Indiana University School of Medicine (IU). IU is the largest medical school in the US and will undertake a ‘Proof of Concept’ study using Cardio inCode-SCORE for the risk assessment of patients for onset of atherosclerotic cardiovascular disease, which accounts for over 85 per cent of all cardiovascular disease deaths and is the leading cause of morbidity and mortality in the US and globally.

Cardiovascular disease disproportionately affects people of lower socioeconomic status, and those of non‐white ethnicity. Early identification of subclinical disease in the population can lead to better primary prevention of heart attack and stroke. Current American College of Cardiology (“ACC”) guidelines call for risk stratification using validated instruments, such as the US National Heart Lung and Blood Institute (“NHLBI”) pooled risk cohort equation, drawing on clinical parameters readily available such as blood pressure and cholesterol levels. In addition, the guidelines endorse the use of “risk enhancing factors” such as the Coronary Artery Calcium (“CAC”) score, undertaken using computerised tomography (“CT”) imaging of the coronary arteries.

Whilst acknowledging family history as a risk factor, current guidelines have not yet incorporated the potential of genetic risk assessment in the prediction of ASCVD. Cardio inCode-SCORE provides an opportunity to apply advanced polygenic testing to improve patient risk assessment and prognosis, in a widely available form and at reduced cost compared with other test modalities.

The primary aim of the IU study is to evaluate the association between the Cardio inCode-SCORE genetic risk score (“GRS”) and the presence of subclinical coronary atherosclerosis evaluated by CAC.

Matthew Walls, CEO, GENinCode said: “We are delighted to work with the IU School of Medicine and to introduce Cardio inCode-SCORE to the IU health community. The IU study follows on from our recently published US clinical performance studies showing the substantive predictive capability of the Cardio inCode-SCORE product for the risk assessment of patients for the onset of cardiovascular disease. We look forward to working closely with the IU team to successfully deliver the programme.”



Nicky Godding is editor of The Business Magazine. Before her journalism career, she worked mainly in public relations moving into writing when she was invited to launch Retail Watch, a publication covering retail and real estate across Europe.

After some years of constant travelling, she tucked away her passport and concentrated on business writing, co-founding a successful regional business magazine. She has interviewed some of the UK’s most successful entrepreneurs who have built multi-million-pound businesses and reported on many science and technology firsts.

She reports on the region’s thriving business economy from start-ups, family businesses and multi-million-pound corporations, to the professionals that support their growth and the institutions that educate the next generation of business leaders.

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